Abstract: The relation between dehydrogenase activity and soil chemical property was determined through path analysis of wasteland in Yellow River Delta in order to evaluate the influence of soil chemical property on dehydrogenase activity. The results show that standard multiple regression equation with a set of independent variables (chemical properties) can explain 84.63% of catalase activity variance and 88.03% of peroxidase activity variance, with 0.392 0 and 0.346 0 of the residual path coefficients respectively. Available K and organic matter have strong positive effect on catalase activity. Available K has significant positive effect on peroxidase activity, while the effect of total N is negative.