Abstract: Based on the principles of eco-economics and systems engineering a study on comprehensive development of the Kerrchin desert with Naiman Banner as an example has been conducted,In this study two aspects are covered.One is from macroscopic view,an integral tactical research is carried out by the principle of coordinated development of eco-environment and social economic.The other is from microscopic view,optimal models for different types of regions and different administrative levels are established,In a further step six large eco-engineering and six large expliotation projects are implemented,with which remarkable social,economical and ecological benefits are achieved.